Designation given to the Fathers of Antioch, who insisted more on the so-called grammatico-historical sense of the Holy Scripture than its moral and allegorical meaning. They steered a course between Origen and Theodore, avoiding the excesses of both, and thus laying the foundation of the principles of interpretation which Catholic exegetes follow. The principal representatives of the school are: John Chrysostom, Theodore of Mopsuestia, Isidore of Pelusium, and Theodoret, Bishop of Cyrus.