Lucas 4:33

And in the synagogue there was a man, that had a spirit of an unclean demon; and he cried out with a loud voice, Ah, what have we to do with thee, Jesus thou Nazarene? art thou come to destroy us? I know thee who thou art, the Holy One of God.

The fact of demon possession is undeniably taught in the Gospels, nor can the fact of it be rationalized out of existence by the supposition that Jesus merely accommodated himself to popular prejudice, or by supposing that the afflicted merely had such diseases as lunacy or epilepsy. The words of the sacred narratives are too explicit to be accommodated to any such devices. In this passage, the demon is represented as addressing the Christ by one of his proper titles, and as having knowledge of the destruction that Jesus would bring upon the demonic world. This is a large subject; and for a more comprehensive discussion of it, see my Commentary on Mark, Mark 1:24, and in my Commentary on Matthew, Matthew 8:16,28.