Luke 21:12

But before all these things, they shall lay their hands on you, and shall persecute you, delivering you up to the synagogues and prisons, bringing you before kings and governors for my name's sake.

The application of these verses through Luke 21:19 are primarily to the twelve apostles, this being implicit in the fact of four apostles being named by Mark as precipitating this prophecy; and when Jesus said to them, "They shall lay their hands upon YOU, etc." there can hardly be any way to avoid the inference that the Twelve are meant. Of course, as throughout the discourse, it applies also to the times of the End.

Synagogues ... kings and governors ... Thus the persecuting power against the Twelve and the infant church would be doubly prosecuted, by both Jews and Gentiles. The Book of Acts, in its entirety, is an inspired comment on the prophecy here. These things all came to pass exactly as Jesus said.