Acts 13:46

And Paul and Barnabas spoke out boldly, and said, It was necessary that the word of God should first be spoken to you. Seeing ye thrust it from you, and judge yourselves unworthy of eternal life, lo, we turn to the Gentiles. For so hath the Lord commanded us, saying, I have set thee for a light of the Gentiles, That thou shouldest be for salvation unto the uttermost part of the earth.

First be spoken to you ... The invariable rule, both of Christ and of the apostles who delivered his message to men, was "to the Jew first, and also to the Greek." Jesus twice fed the multitudes, the first being a great Jewish throng, the second being composed largely of Gentiles.

Judge yourselves unworthy of eternal life ... To reject the Scriptures is to prove unworthiness to receive eternal life.

Lo, we turn to the Gentiles ... Nothing could have been said which would more completely have "turned off" Paul's hearers. It was simply not in their thinking at all that salvation could be offered to any except their own race. What is so amazing about this is that there were many Jewish Scriptures which plainly indicated that through them, that is through the Jews, God intended to redeem the Gentiles also. The quotation here is from Isaiah 49:6; but this is only one of many. In Romans Paul cited Hosea 1:10; 2:23; and Isaiah 65:2 as indicative of God's purpose of saving Gentiles.