2 Corinthians 2:12

Now when I came to Troas for the gospel of Christ, and when a door was opened unto me in the Lord, I had no relief for any spirit, because I found not Titus my brother: but taking my leave of them, I went forth into Macedonia.

I had no relief ... Paul had gone to Troas after the riot at Ephesus (on his way to Macedonia) as recorded in Acts 20:1; and, from what is said here, it is clear that great opportunities for the gospel strongly inclined Paul to take advantage of those opportunities; but the anxious uncertainty that he felt because of the still unresolved situation in Corinth made it impossible for him to remain. Titus' meeting with him there, as evidently planned, did not occur; and as almost a year had passed since his epic letter had been sent (1Corinthians), he decided to press on into Macedonia in the hope of meeting Titus on the way. That reassuring meeting with Titus came to Paul's mind as these words were written; and the news was so encouraging that he burst into an extended expression of praise and thanksgiving to God, forming a rather lengthy parenthesis between this mention of Titus and the resumption of his line of thought again in 2 Corinthians 7:5.