Isaiah 27:10

"For the fortified city is solitary, a habitation deserted and forsaken, like the wilderness: there shall the calf feed, there shall he lie down and consume the branches thereof."

This is once more a reference to that time-period mentioned in Revelation 16:9, near the close of the dispensation of the grace of God, when the "cities of the nations" shall fall. This will occur at a time when Adam's race shall almost have run its course, and when, due to rampant wickedness, God will have no moral choice available except to destroy the sinful world.