Isaiah 40:27

The Judahites kept saying: "How can God do this to us? He has forgotten us and no longer cares about us." They questioned God’s nature (He could not see them) and His dealings with them (He would not defend them).

Perhaps the double names "Jacob" and "Israel" are more than poetic synonyms. Isaiah may have been implying that the Judahites, God’s covenant people, were in a position as desperate in their own eyes as was Jacob, when he came to the end of himself, and God changed his name (Genesis 32:22-32). [Note: Motyer, p. 307.] This happened, they would remember, after his exile in Mesopotamia.

God is not too great to care. He is too great not to care (cf. Genesis 18:25).