Daniel 11:4

After conquering most of the ancient world, even farther east than the Persian Empire had extended, Alexander died prematurely in Babylon, his imperial capital, in 323 B.C. His two sons, Hercules and Alexander, were both murdered when they were very young, as was his uncle, Philip Arrhidaeus. Consequently, his kingdom eventually was divided up between his four leading generals (cf. Daniel 7:6; Daniel 8:8; Daniel 8:22). Cassander ruled Macedonia-Greece, Lysimachus governed Thrace-Asia Minor, Seleucus took the rest of Asia except lower Syria and Palestine, and Ptolemy reigned over Egypt and Palestine. This Greek Empire following Alexander’s demise did not retain the strength that it had previously under the centralized authority of Alexander.