2 Timothy 4:21

Winter severely restricted travel in some parts of the Roman world. Timothy needed to leave Ephesus soon so he could reach Rome without undue difficulty. Paul relayed the greetings of four other brethren, probably local, who Timothy evidently knew, as well as the greetings of all the local Christians.

"Linus is mentioned by Irenaeus (Against Heresies, iii.3) as the first bishop of Rome after the death of Peter and Paul." [Note: Earle, "2 Timothy," pp. 417-18.]