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Verse 2

16:2 {2} And the first went, and poured out his vial upon the earth; and there fell a noisome and grievous sore upon the men which had the {3} mark of the beast, and [upon] them which worshipped his image.

(2) The history of the first angel, whose plague on the earth is described almost in the same words with that sixth plague of the Egyptians in Exodus 9:9 . But it does signify a spiritual vicar, and that torture or butchery of conscience seared with a hot iron, which accuses the ungodly within, and both by truth of the word (the light of which God has now so long shown forth) and by bitterness stirs up and forces out the sword of God’s wrath.

(3) See Revelation 13:16

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