(1):

(n.) Weariness from bodily labor or mental exertion; lassitude or exhaustion of strength.

(2):

(n.) The cause of weariness; labor; toil; as, the fatigues of war.

(3):

(n.) The weakening of a metal when subjected to repeated vibrations or strains.

(4):

(n.) To weary with labor or any bodily or mental exertion; to harass with toil; to exhaust the strength or endurance of; to tire.