(1):

(n.) Want of force or effect; unimportance; pettiness; inefficacy; as, the insignificance of human art.

(2):

(n.) The condition or quality of being insignificant; want of significance, sense, or meaning; as, the insignificance of words or phrases.

(3):

(n.) Want of claim to consideration or notice; want of influence or standing; meanness.