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Want to know what the Bible says about Despondency? Here are 36 Bible verses about Despondency from the Old and New Testaments of the Holy Bible, New International Version (NIV), sorted from the most relevant to the least relevant.

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Note: Always check the context of a verse; Click the "Read Full Chapter" button next to each verse to read more. The context of a verse might put a very different slant on what the verse seems to say.

Genesis 4:13-14 NIV
13 Cain said to the Lord, “My punishment is more than I can bear. 14 Today you are driving me from the land, and I will be hidden from your presence; I will be a restless wanderer on the earth, and whoever finds me will kill me.”
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Genesis 21:15-16 NIV
15 When the water in the skin was gone, she put the boy under one of the bushes. 16 Then she went off and sat down about a bowshot away, for she thought, “I cannot watch the boy die.” And as she sat there, she began to sob.
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Exodus 4:1 NIV
Moses answered, “What if they do not believe me or listen to me and say, ‘The Lord did not appear to you’?”
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Exodus 4:10 NIV
Moses said to the Lord, “Pardon your servant, Lord. I have never been eloquent, neither in the past nor since you have spoken to your servant. I am slow of speech and tongue.”
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Exodus 4:13 NIV
But Moses said, “Pardon your servant, Lord. Please send someone else.”
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Exodus 6:12 NIV
But Moses said to the Lord, “If the Israelites will not listen to me, why would Pharaoh listen to me, since I speak with faltering lips ?”
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Exodus 14:15 NIV
Then the Lord said to Moses, “Why are you crying out to me? Tell the Israelites to move on.
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Numbers 11:15 NIV
If this is how you are going to treat me, please go ahead and kill me —if I have found favor in your eyes—and do not let me face my own ruin.”
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Exodus 6:9 NIV
Moses reported this to the Israelites, but they did not listen to him because of their discouragement and harsh labor.
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1 Kings 19:4 NIV
while he himself went a day’s journey into the wilderness. He came to a broom bush, sat down under it and prayed that he might die. “I have had enough, Lord,” he said. “Take my life; I am no better than my ancestors.”
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Jonah 4:3 NIV
Now, Lord, take away my life, for it is better for me to die than to live.”
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Jonah 4:8 NIV
When the sun rose, God provided a scorching east wind, and the sun blazed on Jonah’s head so that he grew faint. He wanted to die, and said, “It would be better for me to die than to live.”
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Acts 27:20 NIV
When neither sun nor stars appeared for many days and the storm continued raging, we finally gave up all hope of being saved.
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Isaiah 35:3-4 NIV
3 Strengthen the feeble hands,
    steady the knees that give way;
4 say to those with fearful hearts,
    “Be strong, do not fear;
your God will come,
    he will come with vengeance;
with divine retribution
    he will come to save you.”
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Luke 18:1-8 NIV
18 Then Jesus told his disciples a parable to show them that they should always pray and not give up. 2 He said: “In a certain town there was a judge who neither feared God nor cared what people thought. 3 And there was a widow in that town who kept coming to him with the plea, ‘Grant me justice against my adversary.’
4 “For some time he refused. But finally he said to himself, ‘Even though I don’t fear God or care what people think, 5 yet because this widow keeps bothering me, I will see that she gets justice, so that she won’t eventually come and attack me!’”
6 And the Lord said, “Listen to what the unjust judge says. 7 And will not God bring about justice for his chosen ones, who cry out to him day and night? Will he keep putting them off? 8 I tell you, he will see that they get justice, and quickly. However, when the Son of Man comes, will he find faith on the earth?”
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Hebrews 12:12-13 NIV
12 Therefore, strengthen your feeble arms and weak knees. 13 “Make level paths for your feet,” so that the lame may not be disabled, but rather healed.
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