John Gills Exposition of the Bible Commentary - Genesis 4:16
And Cain went out from the presence of the Lord ,.... Either from the place where the Lord was talking with him; or from the place where his glorious Majesty usually resided, where was some visible token of his presence, some stream of light and glory which showed him to be there, and which was at the east of the garden of Eden; from whence Cain was obliged to go, not being suffered to appear any more before God, or among his worshippers: there was a place near Tripoli in Syria, near where... read more
Matthew Henry's Complete Commentary - Genesis 4:16-18
We have here a further account of Cain, and what became of him after he was rejected of God. I. He tamely submitted to that part of his sentence by which he was hidden from God's face; for (Gen. 4:16) he went out from the presence of the Lord, that is, he willingly renounced God and religion, and was content to forego its privileges, so that he might not be under its precepts. He forsook Adam's family and altar, and cast off all pretensions to the fear of God, and never came among good people,... read more