1 Thessalonians 2:15

who both killed the Lord Jesus and the prophets, and drove out us, and please not God, and are contrary to all men;

There are several important considerations that are touched upon in this verse: (1) All modern attempts to mitigate the guilt of the Jews in killing Jesus (by the device of saying the Romans actually did the killing) "are crushed by this passage."[26] Yes, the Jews were guilty. Of course, they were not alone in their guilt. All people, one way or the other, were involved in the death of Christ. See my Commentary on Romans, pp. 127-133 for extended discussion of "Who Crucified Jesus?" (2) This verse refutes the objections some have expressed regarding the gospel of John, affirming that John, a Jew, could not so consistently have referred to "the Jews" as enemies of Christ and Christianity; but Paul, the devout Hebrew of the Hebrews, not only exposes the error of such a view but states in this verse the reasons that lay behind God's judgment of the Jews (see under next verse). (3) The hardening of Israel (see my Commentary on Romans, pp. 392-395) had reached a final stage leading to the destruction of the city of Jerusalem, an event less than two decades future from the time Paul wrote.

Killed the Lord Jesus ... The New Testament account of the opposition to Jesus that culminated in his heartless crucifixion lies behind these brief words. There was no extenuation of guilt in those who through deceit, suborned testimony, mob violence and bitter hatred contrived through intimidation and political pressure the crucifixion of the Lord of glory. Terrible as that was, however, it was not the last straw. The straw that broke the camel's back, as far as God's dealings with Israel were concerned, took place right there in Thessalonica, where they forbade that the gospel of God be preached to Gentiles. That did it! That "filled up" the measure of their sins, and judgment soon fell.