Luke 22:22

Jesus then affirmed again that He was going to die and thereby fulfill God’s plan (cf. Acts 2:23; Acts 10:42; Acts 17:31; Romans 1:4). Luke used a strong word (Gr. horismemon, "determined" or "decreed") to stress God’s sovereignty in these affairs. The title "Son of Man" helped the disciples appreciate that this was part of God’s will for the Messiah who would reign. Jesus pronounced woe on the betrayer as He had on the religious leaders and on Jerusalem for rejecting Him. There is a play on the word "man" (Gr. anthropos). The worst of men would betray the best of men. Note also the reference to both divine sovereignty and human responsibility in this verse (cf. Acts 2:23).