This is memorable in the annals of the church as the city where the disciples were first called Christians, Where an assembly of Gentiles was gathered, and from which Paul and his companions went forth on their missionary journeys, and to which they twice returned. It formed a centre for their labours among the Gentiles, outside the Jewish influence which prevailed at Jerusalem; yet the church in this city maintained its fellowship with the assembly at Jerusalem and elsewhere. Acts 6:5; Acts 11:19-30; Acts 13:1; Acts 14:26; Acts 15:22-35; Acts 18:22; Galatians 2:11 .

Antioch was once a flourishing and populous city, the capital of Northern Syria, founded by Seleueus Nicator, B.C. 300, in honour of his father Antiochus. It was afterwards adorned by Roman emperors, and was esteemed the third city was eventually the seat of the Roman proconsul of Syria. It stood on a beautiful spot on the river Orontes, where it breaks through between the mountains Taurus and Lebanon. It is now called Antakia 36 12', 36 10' E. It has suffered from wars and earthquakes, and is now a miserable place. Comparatively few antiquities of the ancient city are to be found, but parts of its wall appear on the crags of Mount Silpius.