Amphipolis (am-fĭp'o-lĭs), around the city. A chief city of the southern portion of Macedonia under the Romans. The river Strymon flowed on three sides of the city, hence its name. It was 33 miles southwest of Philippi, and three miles from the sea. Paul and Silas passed through it. Acts 17:1. Neo-khorio, or Newtown, a village of about 100 houses, now occupies a portion of the site of Amphipolis.