1: ἀσθένεια
(Strong's #769 — Noun Feminine — astheneia — as-then'-i-ah )

lit., "want of strength" (a, negative, sthenos, "strength"), "weakness," indicating inability to produce results, is most frequently translated "infirmity," or "infirmities;" in Romans 8:26 , the RV has "infirmity" (AV, "infirmities"); in 2—Corinthians 12:5,9,10 , "weaknesses" and in 2—Corinthians 11:30 , "weakness" (AV, "infirmities"); in Luke 13:11 the phrase "a spirit of infirmity" attributes her curvature directly to satanic agency. The connected phraseology is indicative of trained medical knowledge on the part of the writer.

2: ἀσθένημα
(Strong's #771 — Noun Neuter — asthenema — as-then'-ay-mah )

akin to No. 1, is found in the plural in Romans 15:1 , "infirmities," i.e., those scruples which arise through weakness of faith. The strong must support the infirmities of the weak (adunatos) by submitting to self-restraint.

Luke 7:21