1: γραφή
(Strong's #1124 — Noun Feminine — graphe — graf-ay' )

akin to grapho, "to write" (Eng., "graph," "graphic," etc.), primarily denotes "a drawing, painting;" then "a writing," (a) of the OT Scriptures, (1) in the plural, the whole, e.g., Matthew 21:42; 22:29; John 5:39; Acts 17:11; 18:24; Romans 1:2 , where "the prophets" comprises the OT writers in general; 15:4; 16:26, lit., "prophetic writings," expressing the character of all the Scriptures; (2) in the singular in reference to a particular passage, e.g., Mark 12:10; Luke 4:21; John 2:22; 10:35 (though applicable to all); 19:24,28,36,37; 20:9; Acts 1:16; 8:32,35; Romans 4:3; 9:17; 10:11; 11:2; Galatians 3:8,22; 4:30; 1—Timothy 5:18 , where the 2nd quotation is from Luke 10:7 , from which it may be inferred that the Apostle included Luke's Gospel as "Scripture" alike with Deuteronomy, from which the first quotation is taken; in reference to the whole, e.g., James 4:5 (see RV , a separate rhetorical question from the one which follows); in 2—Peter 1:20 , "no prophecy of Scripture," a description of all, with special application to the OT in the next verse; (b) of the OT Scriptures (those accepted by the Jews as canonical) and all those of the NT which were to be accepted by Christians as authoritative, 2—Timothy 3:16; these latter were to be discriminated from the many forged epistles and other religious "writings" already produced and circulated in Timothy's time. Such discrimination would be directed by the fact that "every Scripture," characterized by inspiration of God, would be profitable for the purposes mentioned; so the RV. The AV states truth concerning the completed Canon of Scripture, but that was not complete when the Apostle wrote to Timothy.

John 7:42John 19:37Romans 4:39:17James 4:5 Galatians 3:8Galatians 3:22 Galatians 3:10Matthew 11:13
2: γράμμα
(Strong's #1121 — Noun Neuter — gramma — gram'-mah )

"a letter of the alphabet," etc. is used of the Holy Scriptures in 2—Timothy 3:15 . For the various uses of this word see LETTER.