(1):

(n.) A burdensome sense of responsibility; trouble caused by onerous duties; anxiety; concern; solicitude.

(2):

(n.) Charge, oversight, or management, implying responsibility for safety and prosperity.

(3):

(n.) The object of watchful attention or anxiety.

(4):

(n.) To be anxious or solicitous; to be concerned; to have regard or interest; - sometimes followed by an objective of measure.

(5):

(n.) Attention or heed; caution; regard; heedfulness; watchfulness; as, take care; have a care.