(1):

(superl.) Characterized by refinement and niceness in drawing distinctions; nicely discriminating; - said of persons; as, a subtle logician; refined; tenuous; sinuous; insinuating; hence, penetrative or pervasive; - said of the mind; its faculties, or its operations; as, a subtle intellect; a subtle imagination; a subtle process of thought; also, difficult of apprehension; elusive.

(2):

(superl.) Smooth and deceptive.

(3):

(superl.) Sly in design; artful; cunning; insinuating; subtile; - applied to persons; as, a subtle foe.

(4):

(superl.) Cunningly devised; crafty; treacherous; as, a subtle stratagem.