Depraved (2704) (kataphtheiro from katá = intensifies the meaning + phtheiro = corrupt, destroy) means to corrupt, to destroy (passive - to be destroyed, to perish - used in Greek Textus Receptus of 2Pe 2:12). Here kataphtheiro is used figuratively to describe a human mind that has become corrupted, decadent, entirely spoiled and in a sense "lain waste." There is an especially picturesque use of kataphtheiro in the Lxx of Lev 26:39 So those of you who may be left will rot away (kataphtheiro) because of their iniquity in the lands of your enemies; and also because of the iniquities of their forefathers they will rot away with them. The perfect tense pictures the unalterable, permanently corrupted condition of their minds which in turn explains their utter moral depravity (as described in 2T 3:2, 3, 4, 5). They are like those Paul warns about in (1Ti 4:2) who are "seared in their own conscience as with a branding iron" and whom Jude described as "worldly-minded, devoid of the Spirit" (Jude 1;19). The only other NT use is in 2Peter 2:12 but that is found only in the Greek Textus Receptus version and not in the Nestle-Aland (used for the NAS translation). Kataphtheiro - 27v in the Lxx - Gen 6:12, 13, 17; 9:11; Ex 18:18; Lev 26:39; Jdg 6:4; 2 Chr 12:7; 24:23; 25:16; 26:16; 27:2; 35:21; Isa 10:27; 13:5; 24:1; 32:7; Da 4:14, 27 It is interesting that the first 4 uses of this vivid verb are in the context of God's judgment of mankind by a worldwide flood... (Gen 6:12) God looked on the earth, and behold, it was corrupt; for all flesh had corrupted their way upon the earth. (Gen 6:13) Then God said to Noah, “The end of all flesh has come before Me; for the earth is filled with violence because of them; and behold, I am about to destroy them with the earth. (Gen 6:17) “Behold, I, even I am bringing the flood of water upon the earth, to destroy all flesh in which is the breath of life, from under heaven; everything that is on the earth shall perish. (Gen 9:11) “I establish My covenant with you; and all flesh shall never again be cut off by the water of the flood, neither shall there again be a flood to destroy the earth.”