In Exodus 5 Moses set out to do proceed with God's plan, but he found unexpected issues and difficulties along the way. When hardships came along, he did the right things and called upon God for help.
When you're trying to follow God's plan or the commands he gives you and problems arise, make sure you follow Moses' example and ask God for help.
God's response to Moses was that He is the Lord, so he could get Moses through anything, and that'll be His response to you, too.