“If God be for us, who can be against us?" - that does not mean that faith in God will bring us everything that we desire. What it does mean is that if we possess God, then we can meet with equanimity the loss of all besides. Has it never dawned upon us that God is valuable for His own sake, that just as personal communion is the highest thing that we know on earth, so personal communication with God is the sublimest height of all? If we value God for His own sake, then the loss of other things will draw us all the closer to Him; we shall then have recourse to Him in time of trouble as to the shadow of a great rock in a weary land. I do not mean that the Christian need expect always to be poor and sick and lonely and to seek his comfort only in a mystic experience with His God. This universe is God's world; its blessings are showered upon His creatures even now; and in His own good time, when the period of its groaning and travailing is over, He will fashion it as a habitation of glory. But what I do mean is that if here and now we have the one inestimable gift of God's presence and favour, then all the rest can wait till God's good time.”
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Born in Baltimore, Maryland, he came from a wealthy and well-educated background. He studied at John Hopkins University and then went to Princeton Theological Seminary, receiving an M.A. in philosophy. He studied in Germany and returned to teach New Testament at Princeton. He received his B.D. in 1905 and was ordained in the Presbyterian Church.
In 1929, he left Princeton Seminary when the institution capitulated to the liberal faction, and he, along with others, founded Westminster Theological Seminary. In 1934 he was censured by the Presbyterian Church for his actions in relation to the Presbyterian Board of Foreign Missions, the liberal bias of which he opposed. In 1935 he was defrocked by the Presbyterian Church over major doctrinal issues. Machen then established the Orthodox Presbyterian Church as a reaction to the liberalism of the Presbyterian hierarchy. He died at age 55, of pneumonia.