John Gills Exposition of the Bible Commentary - Isaiah 51:21
Therefore hear now this, thou afflicted ,.... By Babylon, by antichrist and his followers; hear, for thy comfort, the following prophecy: and drunken, but not with wine ; not with wine in a literal sense; nor with the wine of the fornication of the whore of Rome; nor with idolatry, as the kings of the earth are said to be, Revelation 17:2 but, as the Targum expresses it, with tribulation; with afflictions at the hand of God, and persecutions from men. read more
Matthew Henry's Complete Commentary - Isaiah 51:17-23
God, having awoke for the comfort of his people, here calls upon them to awake, as afterwards, Isa. 52:1. It is a call to awake not so much out of the sleep of sin (though that also is necessary in order to their being ready for deliverance) as out of the stupor of despair. When the inhabitants of Jerusalem were in captivity they, as well as those who remained upon the spot, were so overwhelmed with the sense of their troubles that they had no heart or spirit to mind any thing that tended to... read more